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. 2018 Apr 16;14(4):e1007003. doi: 10.1371/journal.ppat.1007003

Fig 1. Coreceptor and CD4 sequences vary in sequence between human, CPZ, GSN and MUS.

Fig 1

CXCR6 and CCR5 were cloned from CPZ, GSN and MUS genomic DNA. Sequences were aligned to the human sequence, and shown are the N-terminus (N term) and the second extracellular loop (ECL2), the two domains thought to interact with the virus glycoprotein, based on studies of human CCR5 and HIV-1 gp120. GSN and MUS CD4 exons were sequenced from genomic DNA and aligned to known sequences of human CD4 and chimpanzee CD4; shown is domain 1 that interacts with HIV/SIV gp120. Residues identical to the human sequence are represented as dots.