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. 2018 Apr 16;14(4):e1007003. doi: 10.1371/journal.ppat.1007003

Fig 4. Amino acid sequences of SIV and HIV V3 loops.

Fig 4

A) The V3 loop amino acid sequences of SIVcpz and SIVmus sequences used in this study (bold text) were aligned with other members of the SIVgsn/mus/mon lineage (plain text) using the ClustalW algorithm. The V3 loop of the previously published SIVmus-01CM1085 that was isolated from the same animal as the SIVmus1085 envs cloned here is identical to that of SIVmus1085 4–1 and 4–12. Residue 326 (SIVmac239 numbering) of the V3 crown is boxed. Conserved residues are shaded in grey. B) The predominant amino acid residues that occur at V3 crown residue 326 (SIVmac239 numbering) or 313 (HIV HXB2 numbering) for SIVs and HIVs where use of CXCR6 has been tested. *SIVmac can use other species’ CXCR6 for entry, but does not efficiently enter through rmCXCR6 due to a S31R polymorphism in the N terminus of rmCXCR6.