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A schematic depicting the hypothesized substrate cycle that NS3h moves through during the NTPase function. Free energy released from this cycle powers the unwinding of dsRNA and unidirectional translocation along the nucleic polymer. The protein structure (inset) demonstrates the tertiary structure of NS3h as well as the positions of the RNA-binding cleft (ssRNA substrate colored blue) and the NTPase active site (ATP molecule colored purple).
