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. 2018 Apr 16;14(4):e1006103. doi: 10.1371/journal.pcbi.1006103

Fig 3. RNA-induced allostery on motif II.

Fig 3

The Asp284 and Glu285 positioning relative to the γ-phosphate of the ATP molecule, for the ATP (A) and ssRNA+ATP (B) systems. In each panel, the highlighted water molecule is identified as the most lytic-like water within the active site. (C) Structural alignment of the same frames shown in (A) and (B), highlighting the RNA-induced backbone shift of residues Glu285 to Asp290. Phe288 and Asp290 are highlighted in both systems due to their prominence in the RNA-binding cleft. (D) RMSD of the backbone atoms of residues 284 to 290 referenced against the ssRNA+ATP crystal structure (PDB ID: 2JLV).