Table I.

Comparisons between therapeutic effects of targeted and untargeted radiation on HCT116 spheroids.

HCT116 Day 10	177Lu-rituximab 30 kBq	177Lu-rituximab 50 kBq	177Lu-rituximab 100 kBq	HCT116 Day 10	131I-rituximab 30 kBq	131I-rituximab 50 kBq	131I-rituximab 100 kBq
177Lu-AbN44v6	p<0.05	ns	ns	131I-AbN44v6	ns	ns	ns
30 kBq				30 kBq
177Lu-AbN44v6	n/a	p<0.0001	ns	131I-AbN44v6	n/a	p<0.05	ns
50 kBq				50 kBq
177Lu-AbN44v6	n/a	n/a	ns	131I-AbN44v6	n/a	n/a	p<0.05
70 kBq				80 kBq
177Lu-AbN44v6	n/a	n/a	p<0.001	131I-AbN44v6	n/a	n/a	p<0.01
100 kBq				100 kBq

Comparisons were made between therapeutic effects of targeted and untargeted radiation on HCT116 spheroids at day 10 post-treatment with ¹⁷⁷Lu-AbN44v6 vs. ¹⁷⁷Lu-rituximab (unspecific) and ¹³¹I-AbN44v6 vs. ¹³¹I-rituximab. Values of p≤0.05, p≤0.01 and p≤0.001 were considered to indicate statistically significant differences or highly statistically significant differences, as appropriate. n/a indicates no comparisons, and ns indicates no significance. For UM-SCC-74B, no significant differences were observed between targeted and non-targeted radiation.