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. 2018 Apr 3;52(6):1934–1946. doi: 10.3892/ijo.2018.4355

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Copyright: © Ren et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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SFRP2 leads to decreased activity of Wnt signaling in AtT20 cells. (A) Overexpression of SFRP2 reduced the levels of β-catenin both in the cytoplasm and nucleus. (B) SFRP2 overexpression reduced the expression of c-myc and β-catenin, and also decreased the phosphorylation but not effect on total of Erk in AtT20 cells. (C) SFRP2 treatment decreased the relative mRNA level of c-myc. ^*P<0.05 and ^**P<0.01 vs. Con or 0 nM. Con, control; SFRP2, secreted frizzled-related protein 2; p-, phospho-; Erk, extracellular signal-regulated kinase.