Figure 3.

Simulated intrinsic stochasticity of gene expression. We simulated gene expression variability due to intrinsic gene expression noise using the Gillespie algorithm (Gillespie 1977) under the random telegraph model for one-dose genes without and with compensation (light and medium green) and two-dose genes (dark green) for increasing numbers of cells in the population. Mean expression of one-dose genes is reduced by half or the same as expression of two-dose genes, for one-dose genes without and with compensation, respectively.