Figure 6.

Filtering of variants by phenotype generates a map of possible modifying loci contributing to cleft palate or exencephaly. (A) Number of SNPs in each 10 Mb window (1 Mb overlap) specific to samples with cleft palate (n = 5). Arrows indicate regions where one SNP was tested for association, bars indicate a locus where more than one SNP has been tested. (B) The same parameters used in (A) were applied to the sequencing data from our samples with exencephaly (n = 3). SNP, single nucleotide polymorphism.