Table 1. χ2 analysis of cleft palate and exencephaly indicates that both phenotypes are contingent with the fosse mutant phenotype.
Phenotype | fosse Observed | Wild-Type Expected | Wild-Type Observed |
---|---|---|---|
Unaffected | 51 (82.3%) | 128 | 155 |
Cleft Palate | 11 (17.7%) | 27 | 0a |
aP < 0.0001 | |||
Unaffected | 46 (74.2%) | 115 | 155 |
Exencephaly | 16 (25.8%) | 40 | 0a |
aP = 0.0009 | |||
Total Embryos | 62 | 155 |
P-values indicate that the lack of cleft palate and exencephaly in unaffected littermates is a significant deviation from ratio observed among the fosse cohort (percentages in parentheses).