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. 2017 Dec 9;8(2):631–641. doi: 10.1534/g3.117.300447

Table 3. High-confidence RNAi screen results for manganese chloride-treated cells.

FlyBase ID Gene Symbol Human Orthologa Treatment Directionb dsRNAsc Avg Z-Score
FBgn0010217 ATPsynβ ATP5B MnCl2 Down 2 −2.45
FBgn0030263 CG2076 GHITM MnCl2 Down 2 −1.63
FBgn0039223 CG5805 SLC25A44 MnCl2 Down 2 −1.80
FBgn0030768 CG9723 NEMP1,2 MnCl2 Down 2 −1.79
FBgn0062413 Ctr1A SLC31A1 MnCl2 Down 3 −1.90
FBgn0264000 GluRIB GRIA1,2,3,4 MnCl2 Down 2 −1.57
FBgn0029870 Marf MFN2 MnCl2 Down 2 −2.81
FBgn0039302 Nup358 RANBP2 MnCl2 Down 2 −2.17
FBgn0036770 Prestin SLC26A5 MnCl2 Down 2 −2.46
FBgn0021906 RFeSP UQCRFS1 MnCl2 Down 2 −2.74
FBgn0036260 Rh7 OPN4,3 MnCl2 Down 2 −2.09
FBgn0027603 Ulp1 SENP1,2,3,5 MnCl2 Down 2 −1.83
FBgn0031937 CG13795 – MnCl2 Up 2 3.32
FBgn0030030 CG1636 – MnCl2 Up 2 3.20
FBgn0039045 CG17119 CTNS MnCl2 Up 2 2.38
FBgn0250757 CG42235 SLC5A family MnCl2 Up 3 2.92
FBgn0027556 CG4928 UNC93A MnCl2 Up 2 1.71
FBgn0034275 CG5002 SLC26A11 MnCl2 Up 2 1.81
FBgn0037764 CG9459 ELOVL7 MnCl2 Up 2 2.36
FBgn0042701 CR12628 – MnCl2 Up 2 3.10
FBgn0061492 loj TMED6 MnCl2 Up 2 1.95
FBgn0025814 Mgstl MGST1 MnCl2 Up 2 3.10
FBgn0052475 mthl8 – MnCl2 Up 2 2.38
FBgn0032006 Pvr FLT1 MnCl2 Up 2 3.46
FBgn0031760 Tsp26A TSPAN5 MnCl2 Up 2 1.99
FBgn0029508 Tsp42Ea CD63 MnCl2 Up 2 2.92
FBgn0033136 Tsp42Eo – MnCl2 Up 2 2.59
FBgn0033137 Tsp42Ep – MnCl2 Up 2 2.37
FBgn0033139 Tsp42Er – MnCl2 Up 2 1.98
FBgn0022097 Vha36-1 ATP6V1D MnCl2 Up 2 1.64
FBgn0040377 Vha36-3 ATP6V1D MnCl2 Up 2 2.21
FBgn0262511 Vha44 ATP6V1C1 MnCl2 Up 2 2.05
FBgn0263598 Vha68-2 ATP6V1A MnCl2 Up 2 2.57
FBgn0028662 VhaPPA1-1 ATP6V0B MnCl2 Up 2 1.99
FBgn0027779 VhaSFD ATP6V1H MnCl2 Up 3 2.37
FBgn0035432 ZnT63C SLC30A1 MnCl2 Up 2 2.27

ID, identifier; dsRNAs, double-stranded RNAs; Avg, average.

a

Best match ortholog(s) or paralog families are shown (DIOPT score cutoff > 2) (Hu et al. 2011).

b

Down, decreased total ATP levels following plate-based normalization within a treatment group; up, increased total ATP levels following plate-based normalization within a treatment group.

c

Number of unique dsRNAs in the library that target the gene. For all high-confidence hits as shown here, all of the designs resulted in a “hit” as defined by a Z-score > 1.5 or < −1.5 and in the same direction as what was found for other designs targeting the same gene.