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. 2017 Dec 7;8(2):621–630. doi: 10.1534/g3.117.300418

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Copyright © 2018 Brown et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of Robo1 Fn1–3 deletion constructs in robo1 mutant embryos. (A–D) Stage 16 embryos stained with anti-HA (green) and anti-HRP (magenta). Lower images show HA channel alone of the same embryos. Expression of full-length Robo1 in robo1 mutant embryos is able to fully restore the wild-type axon scaffold and proper receptor localization on axons. (B–D) Each of the Robo1 Fn 1–3 variants shows this wild-type scaffold with HA present on longitudinal axons (arrowheads). As in the wild-type background, Robo1ΔFn1 shows higher protein expression in neuronal cell bodies (B, arrowhead with asterisk) and Robo1ΔFn3 protein is not cleared from commissures (D, arrows with asterisk).