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. 2018 Apr 5;7:e31867. doi: 10.7554/eLife.31867

Table 1. Summary of genetic perturbations tested for effects on tuning rates.

Perturbation Direct effect Effect on tuning
GCN5::kanMX Deletion of histone acetyltransferase subunit (acts in ADA, SAGA, SLIK/SALSA complexes) Inhibits
SWR1::kanMX Deletion of H2AZ exchange factor No effect
UBP8::kanMX Deletion of SAGA complex de-ubiquitinase No effect
SIN3::kanMX Deletion of Rpd3S/L histone deacetylase components No effect
HST3::kanMX Deletion of Sir2-family histone deacetylase No effect
HST4::kanMX Deletion of Sir2-family histone deacetylase No effect
ISW2::kanMX Deletion of DNA translocase involved in chromatin remodeling No effect
ASF1::kanMX Deletion of nucleosome assembly factor Accelerates
NUP42::kanMX Deletion of nuclear pore complex component known to be involved in transcriptional memory No effect