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. 2018 Apr 26;8:6630. doi: 10.1038/s41598-018-24340-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TGFβR-1 inhibition abrogates contrast mediated up regulation of pro-fibrotic genes in HK-2 cells. TGFβR-1 inhibition using SB525334 significantly decreases in the average gene expression of Ctgf (A), Tgfβ-1 (B), Tgfβ-2 (C), Col-IVa (D), and matrix metalloproteinase-9 (Mmp-9, E) in HK-2 cells treated with contrast + Tgfβr-1 inhibitor (C + I) compared to contrast alone at 12 hours. Each bar represents the mean ± SEM of three different experiments. Two-way ANOVA with Student t test with Bonferroni correction was performed. Significant differences among HK-2 treated contrast (C) compared to contrast + Tgfβr-1 inhibitor (C + I) or contrast (C) compared to saline (S) are indicated by *P < 0.05.