Table 1.

Phenotypes of Shank3 knockout mice^a

Experiment	Δe4−22	NEX-Shank3	Dlx5/6-Shank3	Drd1-Shank3	Drd2-Shank3
Sociability	- 3 chamber	- 3 chamber	- 3 chamber	- 3 chamber	- 3 chamber
USVs	↓calls	- calls	- calls	- calls	- calls
	↓length	- length	- length	- length	- length
Repetitive behaviors	↑grooming	↑grooming	-grooming	- grooming	- grooming
	↑perseveration	-perseveration	↑perseveration	- perseveration	↑perseveration
Elevated zero maze	↑ exploration	- exploration	↑ exploration	↑ exploration	- exploration
Open Field	↓distance	↑distance	- distance	- distance	- distance
	↓rearing	↑ rearing	↓rearing	↓rearing	↑rearing
Instrumental Learning	↓lever pressing	-lever pressing	-lever pressing	N/A	N/A
Conditioned fear	↑context	- context	- context	N/A	N/A
	- cued	- cued	- cued
Pre-pulse inhibition	↑ PPI	- PPI	↑ PPI	N/A	N/A
	↓startle	- startle	↓startle
Rotarod	↓coordination	↓coordination	- coordination	- coordination	- coordination
Excitability	↑ spiking	N/A	N/A	↑ spiking	↑ spiking
Homer1b/c	↓ in striatum	- in any region	↓ in striatum	↓ in striatum	↓ in striatum
NMDAR currents	N/A	↑ hippocampus	N/A	N/A	N/A
GluN1/GluN2B	- in any region	↑ hippocampus	- in any region	N/A	N/A

^aTargeting Shank3 deletion by different Cre lines (NEX, Dlx5/6, Drd1, and Drd2) recapitulated different subsets of behavioral, electrophysiological, and biochemical features of the global Δe4−22 mice. ↑ indicates an increase, ↓ indicates a decrease, - indicates that the mutant is similar to the wild-type control. N/A indicates not applicable, as the experiment was not conducted