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. 2018 Apr 26;8:6612. doi: 10.1038/s41598-018-24961-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity of fDT-bound anti-CD239 mouse mAbs on breast cancer cells. (a) Flow cytometric analysis of CD239 and HER2 expression in SKBR3 cells. As indicated in the histograms, the solid lines show anti-CD239 (left panel) and HER2 (right panel) mAbs. The grey fill indicates control IgG. SKBR3 cells highly expressed both markers. (b) Cytotoxicity of fDT-bound anti-CD239 mouse mAbs. The antibodies (87202, 87207, and BRIC221) were combined with a fragment of diphtheria toxin lacking the receptor-binding domain (fDT). SKBR3 cells were cultured in the presence of the antibodies alone or with bound fDT. Trastuzumab was used as a therapeutic antibody control. After 4 days’ culture, the number of cells was determined as described in Materials and Methods. fDT-bound antibodies suppressed proliferation of SKBR3 cells.