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. 2018 Apr 26;8:6612. doi: 10.1038/s41598-018-24961-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity of fDT-bound recombinant antibody on CD239-highly positive breast cancer cells. (a) Flow cytometric analysis of CD239 and HER2 expression in SKBR3 and BT474 cells. Solid lines show C7-Fc and trastuzumab antibodies, and grey fill indicates the control Fc recombinant protein. (b) Cytotoxicity of fDT-bound C7-Fc. The recombinant proteins (C7-Fc and Fc) were combined with the fragment of diphtheria toxin (fDT). SKBR3 and BT474 cells were cultured in the presence of the recombinant proteins or fDT-bound recombinant proteins. After 4 days in culture, the number of cells was determined.