Fig. 7. CI-994 ameliorates the loss of NeuN-positive neurons following SCI.

a Decreased cytokine/chemokine expression in the spinal cord of CI-994-treated mice. Cytokine/chemokine levels in CI-994-treated mice were normalized to the levels in DMSO (control)-treated mice. n = 4. b Representative images of immunohistochemical staining of neurons in the gray mater following SCI. Neurons were immunostained with anti-NeuN antibody. Scale bar: 200 μm. c The numbers of neurons in the gray matter from 2 mm rostral to lesioned sites to 2 mm caudal to lesioned sites were calculated at the indicated days after SCI. Results are presented as the mean ± SE of five mice per group. *p < 0.05, **p < 0.01; ANOVA with Tukey–Kramer test. SCI: spinal cord injury