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. 2018 Apr 26;8:6554. doi: 10.1038/s41598-018-24919-6

Figure 2.

Figure 2

Macrophages surround implanted mesh with or without eMSC. Representative images of F4/80 immunostaining in (A) C57BL/6 mice implanted with eMSC/PA + G mesh (upper panel) and PA + G mesh control (lower panel) for 3–30 days, and similarly implanted in (B) NSG mice. Macrophages (F4/80+, green) are shown as percentage of total nucleated cells in the first 100 µm increment around mesh filament in (C) C57BL/6 mice and in (D) NSG mice. Data are mean ± SEM of n = 6 animals/group and analyzed by two-way ANOVA. m, mesh, g, gelatin, white dashed lines, outline of PA + G mesh, yellow dotted lines show the 100 µm increment around mesh analyzed eg in (A, D7). Arrowheads, representative F4/80 macrophages both within and outside the 100 µm increment around PA + G mesh. Scale bars 100 µm.