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. 2018 Apr 26;8:6613. doi: 10.1038/s41598-018-24780-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutations detected by NGS with a >200x coverage and >10% variant allele frequency (VAF). Mutated genes, genomic position and detected mutation in the progressing dysplasia (PD), their associated LSCC (T) and non-progressing dysplasia (NPD) are presented in blue. *The PD1 + PD5 and T1 + T5 samples were sequenced together.