Table 1.

Evaluation of the structural similarity of secreted and cell membrane proteins upregulated in the transcriptome of Aspergillus fumigatus Af293 with their close sequence homologs among known drug target proteins in DrugBank²⁵.

Protein identifier	Structure Source	PDB identifier of template used to create protein structure models	Log2 fold change in transcriptome	UniProt identifier of drug target protein	PDB identifier of drug target protein	TM score	RMSD (Å2)
Afu5g14380	SWISS-MODEL	1MQQ A	1.42	Q8VVD2	1L8N	0.98	0.19
Afu8g01670	SWISS-MODEL	5KSN A	2.34	Q939D2	5L05	0.99	0.28
				P9WIE5	1SJ2	0.97	0.72
Afu1g09900	SWISS-MODEL	3S2C A	1.10	Q9XBQ3	1PZ3	0.91	0.99
Afu6g09740$	PDB (4NTC)	NA	1.27	P66010	4GCM	0.86	2.68
Afu7g06140 #	SWISS-MODEL	3ZYZ A	7.16	P40406	3BMX	0.73	4.06
Afu6g03570 #	SWISS-MODEL	5FJJ A	1.30	P40406	3BMX	0.72	3.29
Afu3g00610 #	ModBase	1GAI A	1.19	P05618	1PAM	0.26	15.24
				P26827	1CIU	0.25	19.25

Note that the last three A. fumigatus proteins italicized in this table are not structurally similar to their close sequence homologs among known drug target proteins. ^$An experimentally solved crystal structure was available from PDB for this protein.

^#These three A. fumigatus proteins are not structurally similar to their close sequence homologs among known drug target proteins.