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. 2018 Apr 26;8:6570. doi: 10.1038/s41598-018-25002-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the main EMT signatures. (a) Compact visualization of 23 genomic alterations. The gene set was altered in 285 (63.9%) of 446 complete samples. Genetic alteration included amplification, deep deletion, mRNA upregulation, mRNA downregulation, truncating mutation, and missense mutation. (b) Overall survival Kaplan-Meier estimate: Cases with alterations (red): total cases: n = 285, cases deceased: n = 107, median survival in months, 74.11; cases without alterations (blue): total cases: n = 161, cases deceased: n = 43, median survival in months: NA (not available).