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. 2018 Apr 26;8:6570. doi: 10.1038/s41598-018-25002-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distinguishing ability of the risk score for the clinical status. (a) The Kaplan-Meier test of the risk score for overall survival. P = 8.932e-08. Prognostic performance of the risk score as shown by the time-dependent receiver operating characteristic (ROC) curve for predicting the 5-year survival. The area under the curve (AUC) = 0.701. Patients were divided into high- and low-risk groups using the risk score. The relationship between survival and the risk score is shown at the top; the risk score curve is presented in the middle; heatmap of patients with 3 signatures is on the bottom. (b) Validation of the risk score in the GEO dataset (GSE29609). The Kaplan-Meier test of the risk score for overall survival (n = 39, p value = 0.00375). Prognostic performance of the risk score as shown by the time-dependent receiver operating characteristic (ROC) curve for predicting the 5-year survival. Area under the curve (AUC) = 0.807.