Table 5.
Generation of thrombin in plasma of multiple sclerosis patients and HS.
| EA vs. EA + NA | ||||||||
|---|---|---|---|---|---|---|---|---|
| EA | EA + NA | p-Value | ||||||
| MS | HS | p-Value | MS | HS | p-Value | MS | HS | |
| Lag time (s) | 612 ± 97 | 564 ± 44 | 0.175 | 561 ± 81 | 487 ± 44 | 0.02 | 0.006 | <0.0001 |
| TTP (s) | 750 ± 109 | 690 ± 51 | 0.132 | 706 ± 91 | 605 ± 51 | 0.007 | 0.014 | <0.0001 |
| Peak (RFU/s) | 13.1 ± 2.3 | 13.4 ± 1.4 | 0.804 | 13.5 ± 2.2 | 14.3 ± 1.5 | 0.335 | 0.153 | 0.008 |
| ETP (RFU) | 2,631 ± 166 | 2,780 ± 136 | 0.042 | 2,748 ± 133 | 2,746 ± 38 | 0.964 | 0.004 | 0.506 |
MS, multiple sclerosis; HS, healthy subjects; ETP, endogenous thrombin potential; EA, ellagic acid; NA, nucleic acid; TTP, time to peak; RFUs, relative fluorescence units; s, seconds.
Student’s t-test was used to compare TG parameters of MS patients with those of HS, while paired Student’s t-test was used to assess differences in TG after NA addition in MS and HS (p-value EA vs. EA + NA).