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. 2018 Apr 20;12:108. doi: 10.3389/fncel.2018.00108

Figure 1.

Figure 1

Pretreatment with artemisinin protected HT-22 cells against glutamate-induced cell death. (A) Artemisinin concentration between 6.25–50 μM did not cause any cytotoxicity in HT-22 cells. (B) Pretreatment with artemisinin for 12 h significantly attenuated glutamate-induced HT-22 cell death in a dose-dependent manner. (C) No protective effect against glutamate-induced toxicity was observed when 25 μM artemisinin was pretreated less than 12 h. (D) Calcein-AM/PI double staining showed that pretreatment with 25 μM artemisinin for 12 h attenuated glutamate-induced HT-22 cell death. Scale bar = 100 μm. #p < 0.05 vs. CON group, *p < 0.05 vs. GLUT group.