Figure 2.

Strategies for multi-omics profiling of single cells. Three major types of molecules relating to biological central dogma (Top). Single cell genomics methods profiling the genome, epigenome, transcriptome, and proteome are shown by different shapes with variable colors (Middle). Single cell multi-omics methods are built by combining different single cell sequencing methods to simultaneously profile multiple types of molecules of a single cell genome wide (Bottom). For example, G&T-seq was built by combining genome (orange) and transcriptome (yellow) to simultaneously detect DNA and RNA of the same cell genome wide.