Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 26;8:6610. doi: 10.1038/s41598-018-24899-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Temporal relationship between the transient [Ca²⁺]_i elevation and changes in the nucleus. (a) Time-lapse imaging of the most apical granular cell in the hind paw of mice systemically expressing Fucci and GCaMP3. Arrow: nuclear signal of red fluorescent protein of Fucci system. Note that the nuclear signal disappeared along with the decrease in the fluorescence of GCaMP3. (b) Time-lapse imaging of the granular and cornified layers of the hind paw skin of GCaMP3 mice injected with Hoechst 33342. Yellow arrowheads: granular cells with elevated fluorescence of GCaMP3. White arrows: intensified fluorescence of Hoechst 33342. Green: GCaMP3; red: mKO2-hCdt1 (a), Hoechst 33342 (b). Scale bars: 20 μm. Results are representative of at least two independent experiments.