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. 2018 Apr 26;8:6597. doi: 10.1038/s41598-018-25044-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Active site analysis of CYP5619A1. (A) Active site cavity of CYP5619A1. The active site cavity is shown with the substrate access channel in grey (hydrophobic site) and red (hydrophilic site) surface. (B & C) Active site view of the binding pocket of CYP5619A1. (B) The pocket is displayed with MOE ActiveLP color coding (Blue: Mild polar; Green: Hydrophobic; Pink: H-Bonding) and shows a pattern of high hydrophobicity. (C) Residues forming the pocket are labelled. The amino acids lining the active site cavity are shown in Table S5. Secondary structures are displayed in red (helices), yellow (sheets) and blue (coils and turns). The heme prosthetic group appearing at the center of the active site is shown along with iron atom in a ball shape.