Table 2.
Comparative amino acid conservation analysis of CYP5619 family with top 10 ranked P450 families12.
| P450 family | Number of member P450s | Kingdom | PROMALS3D conservation index | Rank (highest to lowest conservation) | ||||
|---|---|---|---|---|---|---|---|---|
| 5 | 6 | 7 | 8 | 9 | ||||
| CYP141 | 29 | Bacteria | 0 | 0 | 0 | 0 | 389 | 1 |
| CYP51 | 50 | Bacteria | 11 | 102 | 0 | 0 | 264 | 2 |
| CYP137 | 38 | Bacteria | 145 | 0 | 0 | 0 | 251 | 3 |
| CYP121 | 34 | Bacteria | 0 | 0 | 0 | 0 | 233 | 4 |
| CYP132 | 39 | Bacteria | 175 | 0 | 0 | 0 | 217 | 5 |
| CYP5619 | 23 | Stramenopila (oomycetes) | 118 | 38 | 170 | 0 | 199 | 6 |
| CYP124 | 71 | Bacteria | 52 | 35 | 59 | 0 | 170 | 7 (formerly 6) |
| CYP188 | 67 | Bacteria | 62 | 0 | 100 | 0 | 141 | 8 (formerly 7) |
| CYP123 | 74 | Bacteria | 62 | 0 | 82 | 0 | 137 | 9 (formerly 8) |
| CYP108 | 67 | Bacteria | 52 | 12 | 92 | 0 | 134 | 10 (formerly 9) |
| CYP126 | 78 | Bacteria | 65 | 16 | 98 | 0 | 132 | 11 (formerly 10) |
The conservation index score is obtained as described in the section on methods, following the procedure documented in the literature28. The conservation score (5–9) obtained via PROMALS3D is shown in the table where the number “9” indicates conserved amino acids in P450 members. P450 families were arranged in order of the highest to the lowest number of amino acids conserved.