Fig. 1.

Locomotor activity: mean ± SEM number of infrared beams crossed after oral administration of either 30 mg/kg modafinil or vehicle jellies during time-periods from 15 to 160 min after administration. The wake-promoting effects of modafinil became obvious after the first time-period (“ns” denotes the single time-period where there was no significant difference between the groups), following a greater reduction in exploratory behaviour in the control group. Pharmacokinetic profile: mean ± SEM ng/g modafinil in brain tissue collected at specific time-points (within the first 5 mins of the 15 mins LMA time-periods) after oral administration of 30 mg/kg modafinil. Concentration reduced over time, although high variability at the 30-min time-point (within the 30–45-min time-period) may mask a true peak at the 60 min time-point (within the 60–75 min time-period)