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. 2018 Mar 8;235(5):1545–1556. doi: 10.1007/s00213-018-4865-0

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Masitinib selectively decreases the self-administration of cocaine at the unit dose of 250µg/infusion. After 2 weeks of daily training to self-administer either cocaine, heroin or food, rats were administered masitinib or its vehicle daily (grey panel). As compared to vehicle, masitinib treatment resulted in a marked and sustained reduction in cocaine intake (a). In marked contrast, masitinib treatment had no effect on the maintenance of heroin intake or the number of food pellets earned as compared to vehicle-treated rats (b–c)