Table 2.
5-CSRTT performance
| Measure | PCP + Veh | PCP + cariprazine | PCP + aripiprazole | |||||
|---|---|---|---|---|---|---|---|---|
| 0.03 mg/kg | 0.1 mg/kg | 0.3 mg/kg | 1 mg/kg | 3 mg/kg | 10 mg/kg | |||
| Incorrect responses (%) | Baseline | 4.3 (0.8) | 4.9 (0.8) | 4.9 (0.7) | 5.0 (1.2) | 5.8 (1.1) | 5.6 (0.8) | 4.0 (1.2) |
| Treatment | 7.1 (0.9)* | 5.4 (0.7) | 5.7 (1.4) | 5.5 (1.5) | 6.0 (1.1) | 8.2 (1.2)* | 4.1 (1.2) | |
| Correct reponses (%) | Baseline | 78.4 (3.0) | 79.2 (3.3) | 75.6 (2.1) | 79.2 (3.3) | 79.4 (2.5) | 79.2 (2.3) | 80.3 (3.2) |
| Treatment | 71.4 (3.0) | 76.6 (3.4) | 51.6 (2.6)* | 36.4 (6.0)* | 65.2 (4.9)* | 66.9 (3.0)* | 38.7 (5.2)* | |
| Accuracy (%) | Baseline | 94.7 (1.1) | 94.1 (1.0) | 94.0 (0.9) | 93.9 (1.6) | 93.4 (1.3) | 93.2 (1.1) | 95.0 (1.7) |
| Treatment | 90.8 (1.3) | 93.1 (1.0) | 90.1 (2.4) | 80.3 (4.9)* | 91.0 (1.3) | 88.6 (1.7) | 73.0 (7.5)* | |
| Omissions (%) | Baseline | 17.3(2.6) | 16.0 (3.1) | 19.5 (2.0) | 15.7 (2.9) | 15.0 (2.3) | 15.2 (1.7) | 15.8 (2.4) |
| Treatment | 21.5 (2.1) | 18.0 (3.1) | 42.6 (2.8)* | 58.2 (6.8)* | 28.8 (5.1)* | 24.9 (2.5)* | 57.2 (5.7)* | |
| Trials completed, n | Baseline | 99.1 (0.6) | 99.1 (0.6) | 98.9 (0.7) | 96.6 (2.5) | 99.0 (0.5) | 99.4 (0.4) | 99.1 (0.9) |
| Treatment | 89.1 (5.6) | 97.7 (1.0) | 79.2 (5.9)* | 49.1 (9.8)* | 86.6 (6.3) | 94.6 (2.5) | 56.1 (9.6)* | |
| Premature responses, n | Baseline | 6.7 (1.4) | 10.3 (1.1) | 8.3 (1.7) | 9.7 (2.6) | 11.0 (3.1) | 9.3 (1.7) | 6.8 (1.2) |
| Treatment | 12.8 (3.3)* | 10.1 (1.8) | 3.9 (1.4) | 2.5 (1.2)* | 9.4 (2.4) | 8.2 (2.4) | 2.7 (0.9) | |
| Timeout responses, n | Baseline | 6.8 (1.1) | 7.5 (1.4) | 5.3 (1.0) | 7.8 (1.6) | 7.0 (2.3) | 8.8 (1.6) | 6.2 (1.3) |
| Treatment | 12.9 (3.2)* | 9.4 (1.3) | 4.6 (1.6) | 4.3 (1.5) | 6.6 (1.3) | 14.0 (2.7)* | 5.0 (1.6) | |
| Correct latency (s) | Baseline | 0.8 (0.0) | 0.8 (0.0) | 0.8 (0.0) | 0.8 (0.0) | 0.8 (0.0) | 0.9 (0.0) | 0.8 (0.0) |
| Treatment | 0.8 (0.0) | 0.8 (0.0) | 1.0 (0.0) | 1.0 (0.1) | 0.9 (0.1) | 0.9 (0.0) | 0.9 (0.1) | |
| Reward latency (s) | Baseline | 1.8 (0.1) | 1.7 (0.2) | 2.1 (0.2) | 2.1 (0.3) | 1.8 (0.1) | 2.0 (0.2) | 1.7 (0.2) |
| Treatment | 1.6 (0.2) | 1.5 (0.1) | 2.5 (0.3) | 1.8 (0.3) | 1.7 (0.1) | 2.0 (0.2) | 1.5 (0.2) | |
| Perseverative responses, n | Baseline | 6.5 (1.0) | 5.8 (1.2) | 6.8 (1.4) | 9.8 (1.8) | 7.2 (0.7) | 8.7 (2.1) | 7.0 (0.8) |
| Treatment | 7.3 (1.9) | 7.2 (0.8) | 5.6 (1.2) | 2.8 (1.2)* | 8.1 (2.3) | 8.0 (1.2) | 4.7 (1.6) | |
Measures are shown as mean ± SEM
5-CSRTT 5-choice serial reaction time task, PCP phencyclidine, Veh vehicle
*p < 0.05