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. 2018 Apr 20;9:135. doi: 10.3389/fgene.2018.00135

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Copyright © 2018 Han, Mo, Liu, Li, Du, Qiao, Fan, Zhao, Zhang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cisplatin sensitivity of Saos2-lung cells after TIMP3 overexpression in vivo. (A–C) Cisplatin or saline was used to treat nude mice bearing osteosarcoma cells. Saos2-lung cells with and without TIMP3 overexpression were labeled with luciferase and implanted in the tibia. The tumor volume was evaluated via in vivo bioluminescence assay at 1–5 weeks after cisplatin or saline treatment. (D,E) The mice were sacrificed, and the tumor volume was measured and calculated during the 5th week after treatment. The data are presented as the means ± SD. ^∗∗∗P < 0.001, ^∗∗P < 0.01, ^∗P < 0.05. Each group contained five animals.