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. 2018 Apr 20;11:120. doi: 10.3389/fnmol.2018.00120

FIGURE 7.

FIGURE 7

Effects of low-dose morphine on the lifespan of transgenic PD Drosophila models. The lifespan of adult male and female Drosophila of different genotypes were recorded at 25°C. A minimum of one hundred flies for each group were analyzed, and the number of surviving flies were counted daily, and survivorship curves were generated. (A,B) Morphine prolonged the lifespan of Elav-α-synuclein-WT transgenic PD flies. ∗P < 0.05 vs. Elav-α-synuclein-WT group, n = 80–120 flies/group. (C,D) Morphine had no effect on the lifespan of male flies in Elav-α-synuclein genotype, but can shorten the lifespan of female flies. ∗P < 0.05, ∗∗P < 0.01 vs. Elav-α-synuclein-A53T group, n = 80–120 flies/group. (E,F) Morphine prolonged the lifespan of Elav-Q311X transgenic PD male flies, but shortened the lifespan of female flies. ∗P < 0.05 vs. Elav-Q311X group, n = 80–120 flies/group. (G,H) Morphine prolonged the lifespan of Ddc-GS2 transgenic PD male flies, while only morphine (0.05 mg/ml) prolonged the lifespan of female flies. ∗P < 0.05, ∗∗P < 0.01 vs. Ddc-GS2 group, n = 80–120 flies/group. All data are expressed as mean ± SEM.