Table 3.
Significant correlation among MM-genes and lncRNAs nearer than 4 Mb each other.
| MM-Gene Symbol | description | Chr. | lncRNA | R | p-value | lncRNA in MM subgroup | |
|---|---|---|---|---|---|---|---|
| FBXW7 | F-box and WD repeat domain containing 7 | 4q31 | RP11-588K22.2 | 0.42 | 0.016 | DW | t(11;14) |
| CCND2 | cyclin D2 | 12p13 | CCND2-AS1 | 0.95 | 1.50E-16 | DW | |
| CUL4A | cullin 4A | 13q34 | GAS6-AS2 | 0.45 | 0.011 | DW | |
| CCR2 | C-C motif chemokine receptor 2 | 3p21 | RP4-555D20.2 | 0.63 | 1.22E-04 | DW | |
| WWOX | WW domain containing oxidoreductase | 16q23 | RP11-679B19.1 RP11-70D24.2 |
0.53 0.68 |
0.002 1.77E-05 |
DW DW |
|
| MAF | MAF bZIP transcription factor | 16q23 | RP11-679B19.1 RP11-70D24.2 |
0.42 0.63 |
0.016 1.27E-04 |
DW DW |
|
| RELN | reelin | 7q22 | CTB-107G13.1 | 0.42 | 0.017 | UP | |
| PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | 7q22 | CTB-107G13.1 | 0.45 | 0.009 | UP | |
| PAX5 | paired box 5 | 9p13 | EBLN3 | 0.59 | 4.27E-04 | UP | |
| KREMEN2 | kringle containing transmembrane protein 2 | 16p13 | AC005606.14 | 0.53 | 0.002 | UP | |
| CCL2 | C-C motif chemokine ligand 2 | 17q12 | RP11-848P1.5 | 0.46 | 0.008 | UP | |
| STAT3 | signal transducer and activator of transcription 3 | 17q21 | RARA-AS1 | 0.52 | 0.002 | UP | |
| RARA | retinoic acid receptor alpha | 17q21 | RARA-AS1 | 0.70 | 8.49E-06 | UP | |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 18q21 | RP11-299P2.2 | 0.42 | 0.017 | UP | |
| HGF | hepatocyte growth factor | 7q21 | AC006145.4 | 0.45 | 0.009 | DW | t(4;14) |
| AKT1 | AKT serine/threonine kinase 1 | 14q32 | RP11-731F5.2 | 0.43 | 0.013 | DW | |
| DNMT1 | DNA methyltransferase 1 | 19p13 | CTD-3214H19.6 | 0.41 | 0.021 | DW | |
| CD81 | CD81 molecule | 11p15 | RP11-326C3.2 | 0.70 | 9.41E-06 | DW | |
| PTGS2 | prostaglandin-endoperoxide synthase 2 | 1q31 | GS1-115G20.1 | 0.71 | 5.05E-06 | UP | |
| TNFRSF1A | TNF receptor superfamily member 1A | 12p13 | RP5-1063M23.2 | 0.80 | 4.32E-08 | UP | |
| PAK2 | p21 (RAC1) activated kinase 2 | 3q29 | LMLN-AS1 | 0.49 | 0.005 | UP | |
| ADAM9 | ADAM metallopeptidase domain 9 | 8p11 | RP11-350N15.6 | 0.44 | 0.013 | UP | |
| DICER1 | dicer 1, ribonuclease III | 14q32 | RP11-433J8.1 | 0.41 | 0.018 | UP | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 12p13 | RP5-1063M23.2 | 0.94 | 2.00E-15 | UP | |
| BCL9 | B-cell CLL/lymphoma 9 | 1q21 | RP11-196G18.22 | 0.67 | 2.58E-05 | DW | HD |
| HIST2H3C | histone cluster 2 H3 family member c | 1q21 | RP11-196G18.22 | 0.53 | 0.002 | DW | |
| ILF2 | interleukin enhancer binding factor 2 | 1q21 | ASH1L-AS1 | 0.59 | 3.52E-04 | DW | |
| DEPTOR | DEP domain containing MTOR interacting protein | 8q24 | KB-1471A8.1 | 0.73 | 2.38E-06 | DW | |
| P2RX7 | purinergic receptor P2X 7 | 12q24 | RP11-347I19.7 | 0.49 | 0.005 | DW | |
| CIITA | class II major histocompatibility complex transactivator | 16p13 | RP11-490O6.2 | 0.61 | 2.10E-04 | DW | |
| NES | nestin | 1q23 | RP11-404F10.2 | 0.41 | 0.020 | DW | MAF trx |
| FCRL4 | Fc receptor like 4 | 1q23 | RP11-404F10.2 | 0.43 | 0.015 | DW | |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 10q21 | PRKG1-AS1 | 0.51 | 0.003 | DW | |
| MBL2 | mannose binding lectin 2 | 10q21 | PRKG1-AS1 | 0.71 | 5.70E-06 | DW | |
| NCAM1 | neural cell adhesion molecule 1 | 11q23 | RP11-629G13.1 | 0.53 | 0.002 | DW | |
| XPO1 | exportin 1 | 2p15 | RP11-373L24.1 RP11-568N6.1 |
0.46 0.53 |
0.009 0.00 |
DW DW |
|
| IFNL1 | interferon lambda 1 | 19q13 | PCAT19 | 0.40 | 0.023 | DW | |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | Xp11 | RP6-99M1.3 MIR222HG |
0.50 0.46 |
0.003 0.009 |
DW DW |
|
| HAVCR2 | hepatitis A virus cellular receptor 2 | 5q33 | AC008697.1 | 0.47 | 0.007 | UP | |
The last column specifies for each lncRNA upregulation (UP) or downregulation (DW) in the specified MM group by DE-seq analysis.