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. 2018 Apr 27;9(5):469. doi: 10.1038/s41419-018-0482-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b FoxM1 knockdown reduced the migration as well as potentialities of adipogenesis and osteogenesis of U251MG and U87MG cells. Scale bar = 100 μm. The data are shown as the mean ± s.d. of three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (***P < 0.001, ^#P < 0.0001, Student’s t test). c The expression of mesenchymal markers and E-cadherin were detected after knocking down FoxM1 by western blot. d, e ADAM17 knockdown inhibited the migration, adipogenesis and osteogenesis of U251MG and U87MG cells. Scale bar = 100 μm. The data are shown as the mean ± s.d. of three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (^#P < 0.0001, Student’s t test). f The expression of mesenchymal markers and E-cadherin were detected after knocking down ADAM17 by western blot. The data are shown as the mean ± s.d. of three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (***P < 0.001, ^#P < 0.0001, Student’s t test)