Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 27;9(5):469. doi: 10.1038/s41419-018-0482-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, b qRT-PCR and western blot were performed to investigated the effects of altering the expression of FoxM1 on that of ADAM17 in glioma cells. The data are means ± SD from three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (^#P < 0.0001, Student’s t test). c The sites and mutant sites of FoxM1 binding to ADAM17 promoter. d FoxM1 overexpression increased the ADAM17 promotor activity. The data are shown as the mean ± s.d. of three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (**P < 0.01, Student’s t test). e The luciferase report assay was used to determine the importance of the binding sites on ADAM17 promoter activity. The data are shown as the mean ± s.d. of three independent experiments. Student’s t test was used to determine the significance of the differences between the groups (*P < 0.05, **P < 0.01, ***P < 0.001, ^#P < 0.0001, Student’s t test). f Results of ChIP assay performed with glioma cells to detect the binding between FoxM1 and ADAM17 promoter