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. 2018 Apr 27;9(5):469. doi: 10.1038/s41419-018-0482-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Heatmap revealed that the expression of FoxM1 and ADAM17 were correlated with that of EGFR in glioblastoma samples from TCGA database. b, c The effects of FoxM1 on EGFR/AKT/GSK3β signaling pathway in glioma cells were investigated by western blot. d The key components of EGFR/AKT/GSK3β signaling were detected after knocking down FoxM1 and overexpressing ADAM17 by western blot in U251MG and U87MG cells. e The effects of FoxM1 upregulation and ADAM17 knockdown on EGFR/AKT/GSK3β signaling pathway were confirmed by western blot in SW1783 and LN229 cells. f U87MG cells were treated with TAPI-2(ADAM17 inhibitor), and then indicated proteins were measured by western blot. g After transfected with sh-ADAM17, U87MG cells were treated with CHX (0, 2, 4, 6 h) and then western blot was used to determine the expression of FoxM1. h FoxM1 levels were measured in MEF GSK3β+/+ and GSK3β−/− cells with CHX (0, 2, 4, 6 h) . i The effects of ADAM17 downregulation on FoxM1 expression in MEF GSK3β+/+ and GSK3β−/− cells. j The levels of indicated proteins were detected by western blot in U87MG-sh-ADAM17 cells treated with CHX and LiCl (0, 2, 4, 6 h)