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. 2018 Apr 27;9(5):464. doi: 10.1038/s41419-018-0515-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative images of tumorigenesis after the subcutaneous injection of luc-shRNA-hYAP1-NEO or luc-shRNA-NEO cells into a xenograft nude mouse model. shYAP1: luc-shRNA-hYAP1-NEO cells; shNEO: luc-shRNA-NEO cells. b Effects of YAP1 knockdown on the size of A549 xenograft tumors in nude mice. c The significantly smaller average tumor weights of the shYAP1 group are compared to their counterparts in the shNEO group. d Representative images of the IHC staining of YAP1, Slug, E-cadherin, and vimentin in the xenograft tumors from nude mice. The scale bars indicate 50 µm. n = 3; *P < 0.01. e Model of the role of YAP1 in NSCLC