Table II.
Correlation between C-MET overexpression and clinicopathological features in 374 patients with stage III colorectal cancer.
| C-MET overexpression | ||||
|---|---|---|---|---|
| Clinicopathological features | Patients, n | No (n=105) | Yes (n=269) | P-value |
| Gender | 0.690 | |||
| Male | 204 | 59 (28.9) | 145 (71.1) | |
| Female | 170 | 46 (27.1) | 124 (72.9) | |
| Age, years | 0.610 | |||
| <65 | 188 | 55 (29.3) | 133 (70.7) | |
| ≥65 | 186 | 50 (26.9) | 136 (73.1) | |
| Tumor location | 0.699 | |||
| Left colon | 166 | 50 (30.1) | 116 (69.9) | |
| Right colon | 46 | 13 (28.3) | 33 (71.7) | |
| Rectum | 162 | 42 (25.9) | 120 (74.1) | |
| Differentiation | 0.103 | |||
| Well/Moderate | 238 | 60 (25.2) | 178 (74.8) | |
| Poor | 136 | 45 (33.1) | 91 (66.9) | |
| Depth of invasion | 0.251 | |||
| T1 | 2 | 0 (0.0) | 2 (100.0) | |
| T2 | 24 | 6 (25.0) | 18 (75.0) | |
| T3 | 284 | 75 (26.4) | 209 (73.6) | |
| T4 | 64 | 24 (37.5) | 40 (62.5) | |
| Nodal stage | 0.019 | |||
| N1 | 260 | 84 (32.3) | 176 (67.7) | |
| N2a | 74 | 15 (20.3) | 59 (79.7) | |
| N2b | 40 | 6 (15.0) | 34 (85.0) | |
| Vascular invasion | 0.023 | |||
| No | 308 | 94 (30.5) | 214 (69.5) | |
| Yes | 66 | 11 (16.7) | 55 (83.3) | |
| Initial CEA, ng/ml | 0.072 | |||
| <20 | 100 | 35 (35.0) | 65 (65.0) | |
| ≥20 | 274 | 70 (25.5) | 204 (74.5) | |
| Late distant metastases | <0.001 | |||
| No | 46 | 23 (50.0) | 23 (50.0) | |
| Liver | 126 | 27 (21.4) | 99 (78.6) | |
| Lung | 68 | 7 (10.3) | 61 (89.7) | |
| Abdomen | 72 | 26 (36.1) | 46 (63.9) | |
| Others | 62 | 22 (35.5) | 40 (64.5) | |
| COX-2 expression | 0.490 | |||
| Negative/Weak | 32 | 10 (31.2) | 22 (68.8) | |
| Moderate | 66 | 22 (33.3) | 44 (66.7) | |
| Strong | 276 | 73 (26.4) | 203 (73.6) | |
| MSI | 0.167 | |||
| MSI-H | 22 | 9 (40.9) | 13 (59.1) | |
| MSI-L/MSS | 352 | 96 (27.3) | 256 (72.7) | |
Data are presented as n (%), unless otherwise stated. C-MET, c-mesenchymal epithelial transition factor; COX-2, cyclooxygenase-2; CEA, carcinoembryonic antigen; MSI, microsatellite instability; MSI-H, MSI-high; MSI-L, MSI-low; MSS, stable MSI.