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. 2018 Apr 4;37(9):e98280. doi: 10.15252/embj.201798280

Figure EV4. Slc1a3 is transiently expressed in active cycling SG and IFE cells.

Figure EV4

  • A
    Percentage of YFP+ SGs after 2 (n = 4, 200 SGs) compared to 5 (n = 4, 200 SGs) consecutive days of tamoxifen injection, assessed at the same time during telogen.
  • B
    Number of YFP+ cell clusters in 10 mm IFE after 2 (n = 4, 40 mm) compared to 5 (n = 3, 30 mm) consecutive days of tamoxifen injection, assessed at the same time during telogen.
  • C
    Schematic depiction of the genetic strategy to block proliferation of Slc1a3+ cells, by tamoxifen inducible cell‐specific deletion of all Ras genes.
  • D, E
    Representative micrographs showing proliferating (Ki67+) cells in SG (D) and IFE (E) after recombination‐mediated block of proliferation in Slc1a3+ cells (Slc1a3‐CreERT2+) compared to control (Slc1a3‐CreERT2−) animals.
Data information: Data are mean ± SEM; *P < 0.05 (two‐tailed Student's t‐test). Dashed lines outline the SG (B) and indicate the epidermal–dermal border (C). Scale bar = 20 μm.Source data are available online for this figure.