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. 2018 Mar 25;37(9):e98026. doi: 10.15252/embj.201798026

Figure 1. Contact‐dependent growth inhibition systems increase antibiotic tolerance.

Figure 1

Average survival of exponentially growing Escherichia coli cells after 3 h of ciprofloxacin (CIP) treatment.
  1. EC93 cells with or without cdiBAI loci (n = 5).
  2. Uropathogenic E. coli 536 (UPEC 536) cells with or without CdiA C‐terminal toxin and immunity (cdiA ΔCT‐I) (n = 7).
  3. MG1655 cells with empty, cdiBA‐CT‐I EC93, cdiBA‐CT‐I UPEC536 or cdiBA‐CT‐I EC869 plasmids (n = 5, 4, 4, 3).
  4. MG1655 cells with chromosomally encoded cdiBA, cdiBA‐CT‐I EC93 or cdiBA‐CT‐I UPEC536 (n = 7, 4, 3).
  5. MG1655 bamA Sty cells with empty, cdiBA‐CT‐I EC93 , cdiBA‐CT‐I UPEC536 or cdiBA‐CT‐I EC869 plasmids (n = 8, 3, 3, 5).
Data information: Scales are logarithmic for (A, C–E) and linear for (B). Error bars represent s.e.m., and n‐values indicate biological replicates. Statistical significance was determined using Mann–Whitney U‐test. *P < 0.05.Source data are available online for this figure.