Table I.

Somatic mutations detected in primary tumor and metastases.

			Allele frequency (%)
Mutation	RNA	Protein	Pancreas (primary)	Brain (metastasis)
BRCA1	NM_007294.3:c.4535G>T	NP_009225.1:p.Ser1512Ile	47	57
P53	c.831T>ANM_001126112.2	NP_000537.3:p.C277*	33	46
K-RAS	NM_004985.4:c.35G>C	NP_004976.2:p.Gly12Asp	44	32
CHEK2	NM_001005735.1:c.1399T>C	NP_001005735.1:p.Tyr467His	50	57

BRCA1, breast cancer 1; CHEK2, checkpoint kinase 2.