Figure 1.

Zebrafish can be used to define and connect changes along the entire spectrum of toxicity research. Zebrafish can be used to model toxicity from the initial intoxication (1), through the molecular initiating event (2), and changes at the cellular (3), tissue (4), and organ (5) levels. Finally, changes in phenotype (6), including alterations in growth and development or behavior and disease outcomes can be observed. In this example, the methylation status of a gene is altered by xenobiotic exposure (2), resulting in altered gene transcription (3), altered neurotransmission (4), and brain dysfunction (5).