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. 2018 Mar 22;141(5):1529–1544. doi: 10.1093/brain/awy050

Figure 3.

Figure 3

Event-based model staging results for dominantly-inherited Alzheimer’s disease. (A) Staging by diagnostic group: all non-carriers are at stage zero (black), and advancing disease stage is correlated strongly with cognitive impairment (green to blue to red). (B) Staging consistency across visits within 3 years of baseline for the n = 30 participants having complete longitudinal data (18 mutation carriers; 16 PSEN1, two APP). Most participants advance to a later stage (disease progresses towards the right). The green circle shows the single participant (a PSEN1 mutation carrier) who regressed from event-based model stage 9 to stage 1, which arose due to discordant amyloid measurements between CSF and PiB-PET at baseline. The blue triangle indicates clinical progression from cognitively normal to MCI. AD = probable dementia due to dominantly-inherited Alzheimer's disease (global CDR > 0.5); BL = baseline; CN = cognitively normal (global CDR = 0); M = month; MCI = very mild dementia consistent with mild cognitive impairment (global CDR = 0.5).