Table 1:
percent difference in bone traits by exposure group (lower dose or upper dose) compared to the sex matched control group
| F1 males |
F1 females |
F2 males |
F2 females |
|||||
|---|---|---|---|---|---|---|---|---|
| Traits | Lower | Upper | Lower | Upper | Lower | Upper | Lower | Upper |
| N | 5 | 15 | 4 | 12 | 18 | 21 | 4 | 12 |
| BW (g) | 3.5% | −0.4% | 9.8% | −6.7% | −0.7% | 1.4% | 9.1% | 0.4% |
| Femur Le (mm) | −1.7% | −0.3% | 0.8% | −1.6% | 0.3% | −1.2% | −0.3% | 0.0% |
| Tt.Ar (mm2) | −9.0% | −7.1% | 2.2% | 0.3% | 1.7% | −2.6% | −3.5% | −4.7% |
| Robustness (mm) | −7.3% | −6.9% | 2.2% | 1.4% | 1.4% | −1.3% | −1.6% | −4.6% |
| Ct.Ar (mm2) | −3.0% | −2.2% | 2.2% | −3.0% | 2.3% | −0.1% | 1.7% | −6.8% |
| Ma.Ar (mm2) | −8.7% | −6.3% | 0.5% | 1.8% | 0.1% | −3.2% | −6.4% | −0.2% |
| TMD (mgHA/cc) | −0.8% | 0.7% | −0.2% | −1.9% | 0.4% | 0.6% | −0.9% | 2.3% |
| Stiffness (N/mm) | −19.6% | −15.9% | 9.8% | −7.6% | 12.8% | 13.7% | 9.2% | −18.2% |
| ML (N) | −13.0% | −17.0% | 9.1% | 1.7% | 14.0% | 6.4% | 9.0% | −13.4% |
| PYD (mm) | −0.6% | 12.0% | −12.0% | 40.2% | −5.3% | 16.8% | 72.0% | −26.9% |
| Work (Nm-m) | −10.6% | −7.3% | 4.2% | 36.6% | 13.4% | 21.9% | 45.0% | −32.1% |
BW and Femur Le are adjusted by age (days). All other traits have been adjusted for BW and age except Ct.Ar and TMD that have been adjusted for BW, age, and robustness. Bold font and shaded cell indicates significant differences (P < 0.05) relative to the sex-matched controls (F1 male: N = 13; F1 female: N = 8, F2 male: N = 18, F2 female: N = 9). Values were calculated from means determined with general linear model ANOVAs.
Abbreviations: BW, body weight; Ct.Ar, cortical area; Femur Le, femur length; HA, hydroxyapatite; Ma.Ar, marrow area, ML, maximum load (in Newtons); PYD, post-yield displacement; TMD, tissue mineral density; Tt.Ar, total cross-sectional area; Work, work-to-fracture.