Figure 2.

Hypothetical pattern of viral transmission during the human monkeypox outbreak in Central Africa in 2015/2016. Cases are shown according to the date of disease onset. The number of the case, description of family ties with the index case, sex, and age for each infected person are shown on the left. The index case corresponds to number 1. The number of days after the estimated beginning of symptoms for the index case are shown at the top. Full arrows show confirmed transmission, whereas dotted arrows correspond to potential transmission. Indeed, we cannot be certain about the potential infectious contact or the date of infection because of the significant travel of the family members and ferryboat driver toward the village and hospital.