Figure 4.

miR-874 regulates osteosarcoma cell invasion by repressing CDK9 expression. The Transwell invasion assay was utilized to analyze the effect of miR-874 on cell invasion of MG-63 cells (magnification, ×40). The groups were as follows: miR-874 mimics (MG-63 cells transfected with miR-874 mimics); pcDNA-CDK9 (MG-63 cells transfected with pcDNA-CDK9); and miR-874 mimics+CDK9 (MG-63 cells co-transfected with miR-874 mimics and pcDNA-CDK9). Data are presented as the mean ± standard deviation from three independent experiments. *P<0.01 vs. control group; **P<0.01 vs. miR-874 mimics group. CDK9, cyclin-dependent kinase 9; miR-874, microRNA-874.