Table 3.
Univariate and multivariate analysis of demographic and imaging covariates for index lesion specific progression free survival (PFS). On multivariate analysis, ADC was the only covariate identified that correlated with PFS.
| Univariate P | Hazard Ratio | Multivariate P | |
|---|---|---|---|
| Age | 0.55 | - | - |
| Gender | 0.89 | - | - |
| Index lesion size | 0.96 | - | - |
| Tumor multifocality | 0.14 | - | - |
| Presence of extra-hepatic disease | 0.05 | 1.0 (0.2–4.3) | 0.98 |
| Presence of ascites | 0.05 | 2.0 (0.5–4.2) | 0.08 |
| Presence of vascular invasion | 0.93 | - | - |
| Presence of lymph node metastasis | 0.006 | 2.9 (0.3–15.3) | 0.2 |
| ADC ≥ 1.01 × 10−3 mm2/s | 0.006 | 0.44 (0.23–0.84) | 0.01 |
| ECOG status | 0.81 | - | - |
| Childs-Pugh score | 1.0 | - | - |
| BCLC classification | 0.59 | - | - |
| Treatment modality | 0.47 | - | - |
| Doxorubicin dose | 0.46 | - | - |
| Yttrium-90 absorbed dose | 0.44 | − | − |
ADC-apparent diffusion coefficient, ECOG-extra-hepatic metastases, BCLC-Barcelona Clinic Liver Cancer.