Table II.
Taylor dataset (23) | TCGA dataset (25) | |||||
---|---|---|---|---|---|---|
Variable | n | Mean ± SD | P | n | Mean ± SD | P-value |
KIF4A expression | ||||||
Benign | 29 | 5.97±0.23 | – | |||
PCa | 150 | 6.23±0.35 | <0.001 | 498 | 0.121±1.569 | – |
Serum PSA | <0.001 | |||||
<4 (ng/ml) | 24 | 6.21±0.34 | 411 | 0.011±1.000 | ||
≥4 (ng/ml) | 123 | 6.21±0.32 | 0.977 | 27 | 1.517±5.048 | |
Age, years | 0.306 | |||||
<66 | 124 | 6.21±0.33 | 352 | 0.075±1.664 | ||
≥66 | 26 | 6.31±0.41 | 0.201 | 143 | 0.235±1.300 | |
Pathological stage | <0.001 | |||||
<T3A | 86 | 6.16±0.24 | 186 | −0.300±0.480 | ||
≥T3A | 55 | 6.27±0.42 | 0.056 | 302 | 0.307±1.245 | |
Gleason score | <0.001 | |||||
<8 | 117 | 6.14±0.24 | 290 | −0.255±0.528 | ||
≥8 | 22 | 6.50±0.47 | <0.001 | 205 | 0.653±2.252 | |
Overall survival | <0.001 | |||||
Alive | 131 | 6.18±0.29 | 485 | 0.069±1.068 | ||
Decease | 19 | 6.57±0.51 | <0.001 | 10 | 2.653±7.752 | |
PSA failure | <0.001 | |||||
Negative | 104 | 6.13±0.24 | 398 | −0.032±0.904 | ||
Positive | 36 | 6.39±0.43 | <0.001 | 91 | 0.524±1.508 |
-, lack of relative information. KIF, kinesin super-family protein; PCa, prostate cancer; PSA, prostate-specific antigen.