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Met suppresses the activation of Akt through the upregulation of PTEN. (A) Representative images of western blotting results for PTEN, p-Akt and Akt in MG63 and U2OS cells with or without 48 h of 10 mM Met treatment. (B) With the same treatment, the protein levels of PTEN, p-Akt and Akt were measured in NC-siRNA- and PTEN-siRNA-transfected osteosarcoma cells. Met, metformin; PTEN, phosphatase and tensin homolog; p-, phosphorylated; NC, negative control; siRNA, small interfering RNA.
